Skip to main content
Microneedling + Exosomes: Why I Recommend the Combination
Back to Blog
Skin Treatments

Microneedling + Exosomes: Why I Recommend the Combination

5 min read
By Dr. Azi Shirazi

How Microneedling Works

Microneedling uses a device with tiny sterile needles (I use the SkinPen, an FDA-cleared device) to create thousands of controlled micro-injuries in the skin. Your body responds by producing new collagen and elastin — the proteins that keep skin firm, smooth, and elastic.

It's controlled damage that triggers controlled healing. The result: improved texture, reduced scarring, smaller pores, and a more even skin tone.

Why Add Exosomes?

Exosomes are tiny signaling vesicles that carry growth factors, proteins, and messenger molecules that support tissue repair. Unlike PRP, they're not drawn from your own blood — I use a plant-derived, lab-processed exosome solution applied topically, so there's no blood draw or centrifuge step involved.

I apply the exosome topical once your microneedling session is complete — not during the procedure or through the micro-channels themselves. Your skin's own healing response from the microneedling is supported by the topical afterward. The goal: faster recovery, more collagen production, and more noticeable improvement per session.

What the Evidence Shows

Exosome therapy is a newer addition to aesthetic medicine, and the research base is still growing. Early clinical data on exosomes paired with microneedling is promising for:

  • Acne scarring — particularly rolling and boxcar scars
  • Fine lines and wrinkles — especially around the eyes and mouth
  • Skin texture — overall smoothness and radiance
  • Hyperpigmentation — when combined with appropriate topicals

I'm not claiming miracles — results vary by individual, and I'll always tell you honestly where the evidence is strong versus still emerging.

What to Expect During Treatment

The process takes about 45–60 minutes:

  1. Numbing — topical anesthetic applied 20–30 minutes before needling
  2. Microneedling — the SkinPen passes over the treatment area in multiple directions
  3. Exosome application — the plant-derived exosome topical is applied to the skin once needling is complete

Most patients describe the sensation as a mild vibrating or sandpaper feeling. The numbing cream handles most of the discomfort.

Recovery

  • Day 1: Skin looks sunburned — red, slightly swollen, warm
  • Day 2: Redness fading, can apply mineral makeup
  • Days 3–5: Mild dryness and possible light flaking
  • Week 2: Skin looks noticeably brighter and smoother

Avoid retinoids, acids, and intense exercise for 3–5 days post-treatment. I'll provide detailed aftercare instructions.

How Many Sessions?

For general skin rejuvenation, 3 sessions spaced 4–6 weeks apart is a solid starting point. For deeper acne scarring, 4–6 sessions may be needed. Results continue to improve for 3–6 months after your last session as collagen remodeling progresses.

A Note on At-Home Microneedling

Those derma-rollers you see online? They're not the same thing. At-home devices use shorter needles (0.25mm vs. the 1.5–2.5mm I use clinically) and can't reach the dermal layer where collagen production happens. They may improve product absorption slightly, but they don't produce the controlled wound-healing response that drives real results.

Worse, shared or improperly sterilized rollers can cause infection or scarring. Professional microneedling with disposable, single-use cartridges is the safe and effective approach.

Pricing

Microneedling: $500 single treatment · $1,200 for a 3-pack. The plant-derived exosome topical add-on is priced at consultation.

Topics
microneedlingexosomescollagenacne scarsskin rejuvenation

Ready to Talk?

Let's discuss whether this treatment makes sense for you.